2044508-48-5
2044508-48-5
Chemical Structure
EGFR-IN-50
- CAS No.: 2044508-48-5
- Formula:C24H26BrN3O4S2
- Molecular Weight:564.51
IUPAC Name: 3-((4-((3-bromophenyl)amino)-6-methoxyquinazolin-7-yl)oxy)propyl 3-(allyldisulfanyl)propanoate
InChIKey: WISOXVRWVHHVTF-UHFFFAOYSA-N
SMILES: C=CCSSCCC(OCCCOC1=CC2=C(C(NC3=CC(Br)=CC=C3)=NC=N2)C=C1OC)=O
Biological Activity: EGFR-IN-50 (Compound 9h) is a potent EGFR inhibitor against L858R resistance mutation (TEL-EGFR-L858R-BaF3: GI50=8 nM, TEL-EGFR-T790M-L858R-BaF3: GI50=6.03 μM). EGFR-IN-50 shows anti-proliferative activity to cancer cells[1].
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EGFR-IN-50 | EGFR-IN-50 (Compound 9h) is a potent EGFR inhibitor against L858R resistance mutation (TEL-EGFR-L858R-BaF3: GI50=8 nM, TEL-EGFR-T790M-L858R-BaF3: GI50=6.03 μM). EGFR-IN-50 shows anti-proliferative activity to cancer cells. | |||||||||||||||||||||
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References
Keywords
