EGFR-IN-50
EGFR-IN-50 (Compound 9h) is a potent EGFR inhibitor against L858R resistance mutation (TEL-EGFR-L858R-BaF3: GI50=8 nM, TEL-EGFR-T790M-L858R-BaF3: GI50=6.03 μM). EGFR-IN-50 shows anti-proliferative activity to cancer cells.
For research use only. We do not sell to patients.
- CAS No.: 2044508-48-5
- Formula: C24H26BrN3O4S2
- Molecular Weight:564.51
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HUVEC | IC50 |
>10 μM
Compound: 9h
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Cytotoxicity against HUVEC assessed as reduction in cell viability measured after 72 hrs by Celltiter-Glo luminescent cell viability assay
Cytotoxicity against HUVEC assessed as reduction in cell viability measured after 72 hrs by Celltiter-Glo luminescent cell viability assay
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[PMID: 32619886] |
EGFR-IN-50 (0-10 μM; 72 h) selectively inhibits NSCLC cell line H3255 (expressing EGFR-L858R) compared to other tumor cells[1].
EGFR-IN-50 (1-10 μM; 72 h) induces cell cycle arrest in G0-G1 phase[1].
EGFR-IN-50 (0.039-10 μM; 4 h) inhibits the phosphorylation of EGFR in H3255 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549, H3255, HepG2, MCF-7, HT-29 and A431 cells
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Concentration:0-10 μM
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Incubation Time:72 hours
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Result:Showed GI50 values of >10, and 0.7873 μM for A549 and H3255 cells, respectively.
Showed IC50 values of >10, 7.309, >10 and 6.703 μM for HepG2, MCF-7, HT-29 and A431 cells, respectively.
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Cell Line:H3255 cells
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Concentration:1, 5, and 10 μM
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Incubation Time:72 hours
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Result:Increased the percentage of H3255 cells in G0-G1 phase from 60.32% to 88.61%.
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Cell Line:H3255 cells
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Concentration:0.039, 0.15, 0.62, 2.5, and 10 μM
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Incubation Time:4 hours
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Result:Inhibited the phosphorylation of EGFR in H3255 cells in a dose-dependent manner.
Chemical Information
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CAS No. 2044508-48-5
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Molecular Weight 564.51
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Formula C24H26BrN3O4S2
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SMILES
C=CCSSCCC(OCCCOC1=CC2=C(C(NC3=CC(Br)=CC=C3)=NC=N2)C=C1OC)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EGFR-IN-50 Related Classifications
HY-146210 Related Classifications
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