2055468-48-7
2055468-48-7
Chemical Structure
PF-06678419
- CAS No.: 2055468-48-7
- Formula:C12H13IO5
- Molecular Weight:364.14
IUPAC Name: (R)-2-hydroxy-2-(4-iodophenethyl)succinic acid
InChIKey: OXORLYRMTHWAKO-GFCCVEGCSA-N
SMILES: [C@@](CCC1=CC=C(I)C=C1)(CC(O)=O)(C(O)=O)O
Biological Activity: PF-06678419 is a sodium-coupled citrate transporter and sodium-dependent dicarboxylate transporter inhibitor. PF-06678419 inhibits citrate uptake by interacting with residues near and outside NaCT’s citrate binding site. PF-06678419 can be used for the research of type 2 diabetes mellitus[1][2].
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PF-06678419 | PF-06678419 is a sodium-coupled citrate transporter and sodium-dependent dicarboxylate transporter inhibitor. PF-06678419 inhibits citrate uptake by interacting with residues near and outside NaCT’s citrate binding site. PF-06678419 can be used for the research of type 2 diabetes mellitus. | |||||||||||||||||||||
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References
- [1]. Huard K, et al. Discovery and characterization of novel inhibitors of the sodium-coupled citrate transporter (NaCT or SLC13A5). Sci Rep. 2015;5:17391. Published 2015 Dec 1. [Content Brief]
- [2]. Pajor AM, et al. Molecular Basis for Inhibition of the Na+/Citrate Transporter NaCT (SLC13A5) by Dicarboxylate Inhibitors. Mol Pharmacol. 2016;90(6):755-765. [Content Brief]
Keywords
