2130982-18-0
Chemical Structure
ODS-2004436
- CAS No.: 2130982-18-0
- Formula:C26H29Cl18FN5O4
- Molecular Weight:528.99
IUPAC Name: (R)-35-chloro-17-(2-(fluoro-18F)ethoxy)-7-isopropyl-13-oxa-2,6,9-triaza-1(4,6)-quinazolina-3(1,2)-benzenacyclotridecaphane-5,8-dione
InChIKey: CUZWIVWWRLVMOQ-ZUGUBGFXSA-N
SMILES: ClC1=CC(NC2=NC=NC3=CC(OCC[18F])=C(OCCCNC([C@@H](C(C)C)N4)=O)C=C23)=C(CC4=O)C=C1
Biological Activity: ODS-2004436 is a small molecule radiotracer that uses positron emission tomography (PET) imaging to measure the activity of the epidermal growth factor receptor (EGFR) in tumors. ODS-2004436 labeled with the radioactive isotope fluorine-18 shows significantly higher uptake in the xenograft models of lung cancer with EGFR mutations compared to the wild-type models, and could be used to distinguish the mutation status. ODS-2004436 can be used to identify EGFR-positive tumors and predict their response to certain reagent treatments, especially for non-small cell lung cancer (NSCLC)[1].
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ODS-2004436 | ODS-2004436 is a small molecule radiotracer that uses positron emission tomography (PET) imaging to measure the activity of the epidermal growth factor receptor (EGFR) in tumors. ODS-2004436 labeled with the radioactive isotope fluorine-18 shows significantly higher uptake in the xenograft models of lung cancer with EGFR mutations compared to the wild-type models, and could be used to distinguish the mutation status. ODS-2004436 can be used to identify EGFR-positive tumors and predict their response to certain reagent treatments, especially for non-small cell lung cancer (NSCLC). | |||||||||||||||||||||
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Keywords
