2135595-04-7
Chemical Structure
GSK3182571
- CAS No.: 2135595-04-7
- Formula:C25H31ClN8O
- Molecular Weight:495.02
IUPAC Name: 2-((2-((4-(4-(3-aminopropyl)piperazin-1-yl)phenyl)amino)-5-chloropyrimidin-4-yl)amino)-N-methylbenzamide
InChIKey: UJADJYISGUHANC-UHFFFAOYSA-N
SMILES: O=C(NC)C1=CC=CC=C1NC2=NC(NC3=CC=C(N4CCN(CCCN)CC4)C=C3)=NC=C2Cl
Biological Activity: GSK3182571 is a non-selective broad-spectrum kinase inhibitor with similar structure to CTx-0294885 (HY-15985). GSK3182571 can induce changes in the thermostability of target proteins in cells. GSK3182571 can be used to explore the effects of drugs on kinase networks and off-target effects in leukemia cell models[1][2].
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GSK3182571 | 98.97% | GSK3182571 is a non-selective broad-spectrum kinase inhibitor with similar structure to CTx-0294885 (HY-15985). GSK3182571 can induce changes in the thermostability of target proteins in cells. GSK3182571 can be used to explore the effects of drugs on kinase networks and off-target effects in leukemia cell models. | ||||||||||||||||||||
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- [1]. Mikhail M Savitski, et al. Tracking cancer drugs in living cells by thermal profiling of the proteome. Science. 2014 Oct 3;346(6205):1255784. [Content Brief]
- [2]. Mateus A, et al. Thermal proteome profiling: unbiased assessment of protein state through heat-induced stability changes. Proteome Sci. 2017 Jun 24;15:13. [Content Brief]
Keywords
