2172819-72-4
Chemical Structure
(S,R,S)-CO-C2-acid
Synonym(s): VH 032 amide-alkylC2-acid
- CAS No.: 2172819-72-4
- Formula:C26H34N4O6S
- Molecular Weight:530.64
IUPAC Name: 4-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-4-oxobutanoic acid
InChIKey: MIVGLJJVHAUZOZ-SELNLUPBSA-N
SMILES: OC(CCC(N[C@@H](C(C)(C)C)C(N1[C@@H](C[C@H](C1)O)C(NCC2=CC=C(C3=C(N=CS3)C)C=C2)=O)=O)=O)=O
Biological Activity: (S,R,S)-CO-C2-acid (VH 032 amide-alkylC2-acid) is a functionalized von-Hippel-Lindau (VHL) protein ligand and linker conjugate, which can be used in the research and development of PROTACs[1].
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(S,R,S)-CO-C2-acid | 98.0% | (S,R,S)-CO-C2-acid (VH 032 amide-alkylC2-acid) is a functionalized von-Hippel-Lindau (VHL) protein ligand and linker conjugate, which can be used in the research and development of PROTACs. | ||||||||||||||||||||
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- [1]. Chan KH, et al. Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds. J Med Chem. 2018 Jan 25;61(2):504-513. [Content Brief]
Keywords
