222315-88-0

DP-b99 Chemical Structure
222315-88-0

Chemical Structure

DP-b99

  • CAS No.: 222315-88-0
  • Formula:C42H64N2O12
  • Molecular Weight:788.96

IUPAC Name: 2,2'-(((ethane-1,2-diylbis(oxy))bis(2,1-phenylene))bis((2-(2-(octyloxy)ethoxy)-2-oxoethyl)azanediyl))diacetic acid

InChIKey: FTGBVHPWUIHWRH-UHFFFAOYSA-N

SMILES: O=C(CN(C1=CC=CC=C1OCCOC2=CC=CC=C2N(CC(OCCOCCCCCCCC)=O)CC(O)=O)CC(O)=O)OCCOCCCCCCCC

Biological Activity: DP-b99 is a blood-brain barrier-permeable inhibitor of CYP2C9 and MMP-9, with a Ki value of 4.655 μM against CYP2C9. DP-b99 inhibits CYP2C9 via apparent non-competitive inhibition, mainly chelates pathological Zn2+ in the membrane environment, attenuates the elevation of intracellular Zn2+ and Ca2+ levels, delays seizure onset and reduces seizure severity, and also prevents MMP-9-dependent dendritic spine remodeling, β-dystroglycan cleavage and gelatinase activity. DP-b99 can be used in the research of acute ischemic stroke, epileptogenesis and stroke[1][2][3].

Cat. No. Product Name Purity Description Pricing
HY-121872 		DP-b99 95.0% DP-b99 is a blood-brain barrier-permeable inhibitor of CYP2C9 and MMP-9, with a Ki value of 4.655 μM against CYP2C9. DP-b99 inhibits CYP2C9 via apparent non-competitive inhibition, mainly chelates pathological Zn2+ in the membrane environment, attenuates the elevation of intracellular Zn2+ and Ca2+ levels, delays seizure onset and reduces seizure severity, and also prevents MMP-9-dependent dendritic spine remodeling, β-dystroglycan cleavage and gelatinase activity. DP-b99 can be used in the research of acute ischemic stroke, epileptogenesis and stroke.
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