2232877-85-7
2232877-85-7
Chemical Structure
KPC-2-IN-1
- CAS No.: 2232877-85-7
- Formula:C13H12BN3O2S
- Molecular Weight:285.13
IUPAC Name: (3-((4-(thiophen-3-yl)-1H-1,2,3-triazol-1-yl)methyl)phenyl)boronic acid
InChIKey: BPZNDAHQRPIUAE-UHFFFAOYSA-N
SMILES: OB(C1=CC=CC(CN2N=NC(C3=CSC=C3)=C2)=C1)O
Biological Activity: KPC-2-IN-1, boronic acid derivative, is a potent KPC-2 inhibitor with Ki of 0.032 μM. KPC-2-IN-1 enhances the activity of cefotaxime in KPC-2 expressing E. coli. KPC-2-IN-1 exhibits well tolerated in human HEK-293 cells, which can be used for the study of E. coli resistance to β-lactam antibiotics[1][2].
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KPC-2-IN-1 | KPC-2-IN-1, boronic acid derivative, is a potent KPC-2 inhibitor with Ki of 0.032 μM. KPC-2-IN-1 enhances the activity of cefotaxime in KPC-2 expressing E. coli. KPC-2-IN-1 exhibits well tolerated in human HEK-293 cells, which can be used for the study of E. coli resistance to β-lactam antibiotics. | |||||||||||||||||||||
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References
- [1]. Zhou J, et al. Triazole-substituted phenylboronic acids as tunable lead inhibitors of KPC-2 antibiotic resistance. Eur J Med Chem. 2022 Jun 28;240:114571. [Content Brief]
- [2]. Zhou J, et al. Boronic acid inhibitors of the class A β-lactamase KPC-2. Bioorg Med Chem. 2018 Jul 15;26(11):2921-2927. [Content Brief]
Keywords
