2236-60-4
Chemical Structure
Pterin
- CAS No.: 2236-60-4
- Formula:C6H5N5O
- Molecular Weight:163.14
IUPAC Name: 2-aminopteridin-4(3H)-one
InChIKey: HNXQXTQTPAJEJL-UHFFFAOYSA-N
SMILES: O=C1NC(N)=NC2=NC=CN=C12
Biological Activity: Pterin is a pteridine with antibacterial activity. Pterin binds to the Fe2+ active site via its carbonyl group, reducing the oxygen activation energy barrier in hydroxylases. Pterin participates in metabolic redox processes. Pterin can be used in research related to cancer, vitiligo, bacterial infections, phenylketonuria, Parkinson's disease, schizophrenia and depression[1][2][3][4][5][6][7][8].
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Pterin | 99.75% | Pterin is a pteridine with antibacterial activity. Pterin binds to the Fe2+ active site via its carbonyl group, reducing the oxygen activation energy barrier in hydroxylases. Pterin participates in metabolic redox processes. Pterin can be used in research related to cancer, vitiligo, bacterial infections, phenylketonuria, Parkinson's disease, schizophrenia and depression. | ||||||||||||||||||||
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- [1]. Gamagedara S, et al. Investigation of urinary pteridine levels as potential biomarkers for noninvasive diagnosis of cancer. Clinica chimica acta; international journal of clinical chemistry. 2011 Jan 14;412(1-2):120-8.
- [2]. Mahendran R, et al. Evaluation of Pterin, a Promising Drug Candidate from Cyanide Degrading Bacteria. Current microbiology. 2018 Jun;75(6):684-693. [Content Brief]
- [3]. Oliveros E, et al. Production and quenching of reactive oxygen species by pterin derivatives, an intriguing class of biomolecules. Pure Appl Chem. 2011;83(4):801–811.
- [4]. Hevener KE, et al. Structural studies of pterin-based inhibitors of dihydropteroate synthase. Journal of medicinal chemistry. 2010 Jan 14;53(1):166-77.
- [5]. Iyer SR, et al. Direct coordination of pterin to Fe enables neurotransmitter biosynthesis in the pterin-dependent hydroxylases. Proceedings of the National Academy of Sciences of the United States of America. 2021 Apr 13;118(15):e2022379118.
- [6]. Zhao Y, et al. Pterin-sulfa conjugates as dihydropteroate synthase inhibitors and antibacterial agents. Bioorganic & medicinal chemistry letters. 2016 Aug 15;26(16):3950-4.
- [7]. Andrade P, et al. Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard. Proceedings of the National Academy of Sciences of the United States of America. 2019 Mar 19;116(12):5633-5642.
- [8]. Rutowski RL, et al. Pterin pigments amplify iridescent ultraviolet signal in males of the orange sulphur butterfly, Colias eurytheme. Proceedings. Biological sciences. 2005 Nov 07;272(1578):2329-35. [Content Brief]
Keywords
