2244458-40-8
Chemical Structure
ARN23765
- CAS No.: 2244458-40-8
- Formula:C30H22F5N3O6
- Molecular Weight:615.50
IUPAC Name: (S)-4-((1-(3-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)(methyl)carbamoyl)phenyl)-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-7-yl)oxy)benzoic acid
InChIKey: LGCLACSGYALGRU-QHCPKHFHSA-N
SMILES: OC(C1=CC=C(C=C1)O[C@H]2CCCC3=C2N(N=C3C(F)(F)F)C4=CC(C(N(C)C5=CC6=C(OC(F)(F)O6)C=C5)=O)=CC=C4)=O
Biological Activity: ARN23765 is a corrector for F508del-CFTR with an EC50 of 38 pM in human bronchial epithelial cells. ARN23765 improves the maturation and function of F508del-CFTR on the cell membrane, affects the ions transport and secretion, and corrects the pathological mechanism of cystic fibrosis (CF)[1].
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ARN23765 | ARN23765 is a corrector for F508del-CFTR with an EC50 of 38 pM in human bronchial epithelial cells. ARN23765 improves the maturation and function of F508del-CFTR on the cell membrane, affects the ions transport and secretion, and corrects the pathological mechanism of cystic fibrosis (CF). | |||||||||||||||||||||
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Keywords
