2251785-27-8
![Cyclo[K(N3)larllt] Chemical Structure](http://file.medchemexpress.cn/product_pic/hy-p11757.gif "Cyclo[K(N3)larllt] Chemical Structure")
Chemical Structure
Cyclo[K(N3)larllt]
- CAS No.: 2251785-27-8
- Formula:C37H67N13O8
- Molecular Weight:822.01
InChIKey: MZZGGOCUXYRRFR-BRGLUAOVSA-N
SMILES: O=C([C@@H](NC1=O)CCCCN=[N+]=[N-])N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H]1[C@H](C)O)=O)CC(C)C)=O)CC(C)C)=O)CCCNC(N)=N)=O)C)=O)CC(C)C
Biological Activity: Cyclo[K(N3)larllt] is a seven-membered cyclic peptide targeting EGFR, with a Kd value of 5.09 μM, and exhibits binding selectivity toward homologous proteins HER2 and HER3. Cyclo[K(N3)larllt] has no cytotoxicity and shows no growth inhibitory effect on cancer cells overexpressing EGFR. Cyclo[K(N3)larllt] can serve as a ligand for EGFR-targeted fluorescent conjugates, which is applicable to the detection of cancers with EGFR overexpression. Cyclo[K(N3)larllt] can be used in the research of colorectal cancer[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Cyclo[K(N3)larllt] | Cyclo[K(N3)larllt] is a seven-membered cyclic peptide targeting EGFR, with a Kd value of 5.09 μM, and exhibits binding selectivity toward homologous proteins HER2 and HER3. Cyclo[K(N3)larllt] has no cytotoxicity and shows no growth inhibitory effect on cancer cells overexpressing EGFR. Cyclo[K(N3)larllt] can serve as a ligand for EGFR-targeted fluorescent conjugates, which is applicable to the detection of cancers with EGFR overexpression. Cyclo[K(N3)larllt] can be used in the research of colorectal cancer. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
Keywords
