Cyclo[K(N3)larllt] 

Cyclo[K(N3)larllt] is a seven-membered cyclic peptide targeting EGFR, with a K_d value of 5.09 μM, and exhibits binding selectivity toward homologous proteins HER2 and HER3. Cyclo[K(N3)larllt] has no cytotoxicity and shows no growth inhibitory effect on cancer cells overexpressing EGFR. Cyclo[K(N3)larllt] can serve as a ligand for EGFR-targeted fluorescent conjugates, which is applicable to the detection of cancers with EGFR overexpression. Cyclo[K(N3)larllt] can be used in the research of colorectal cancer^[1].

Cyclo[K(N3)larllt] (0-100 μM; 72 hr) does not exhibit antiproliferative activity against EGFR-overexpressing SW480 colon cancer cells, with an IC₅₀ >100 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

822.01

C₃₇H₆₇N₁₃O₈

2251785-27-8

cyclo({Lys(N3)}-{D-Leu}-{D-Ala}-{D-Arg}-{D-Leu}-{D-Leu}-{D-Thr})

cyclo({Lys(N3)}-larllt)

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Williams TM, et al. Peptide ligands for targeting the extracellular domain of EGFR: Comparison between linear and cyclic peptides. Chem Biol Drug Des. 2018;91(2):605-619.