2252329-12-5
Chemical Structure
AldRed 588-A
- CAS No.: 2252329-12-5
- Formula:C18H17BF2N4O2
- Molecular Weight:370.16
InChIKey: LGQCHYRKBUYRTB-UHFFFAOYSA-N
SMILES: O=CCNC(CCC1=[N]2[B+3]([F-])([F-])[N-]3C(C4=CC=CN4)=CC=C3C=C2C=C1)=O
Biological Activity: AldeRed 588-A is a fluorescent labeling reagent and a substrate for aldehyde dehydrogenase (ALDH). AldeRed 588-A is metabolized by functionally active ALDH enzymes, thereby specifically labeling viable ALDHbright cell populations with red-shifted fluorescence. AldeRed 588-A supports one-step isolation and sorting of ALDH-expressing cells (including normal stem cells and cancer stem cells), and can be used in combination with green fluorophores for multicolor experimental applications. AldeRed 588-A is widely applicable to research related to various cancers such as bladder cancer, breast cancer, and head and neck cancer[1][2].
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AldRed 588-A | AldeRed 588-A is a fluorescent labeling reagent and a substrate for aldehyde dehydrogenase (ALDH). AldeRed 588-A is metabolized by functionally active ALDH enzymes, thereby specifically labeling viable ALDHbright cell populations with red-shifted fluorescence. AldeRed 588-A supports one-step isolation and sorting of ALDH-expressing cells (including normal stem cells and cancer stem cells), and can be used in combination with green fluorophores for multicolor experimental applications. AldeRed 588-A is widely applicable to research related to various cancers such as bladder cancer, breast cancer, and head and neck cancer. | |||||||||||||||||||||
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- [1]. Dollé L, et al. Next generation of ALDH substrates and their potential to study maturational lineage biology in stem and progenitor cells. Am J Physiol Gastrointest Liver Physiol. 2015;308(7):G573-G578. [Content Brief]
- [2]. Asbrock N, et al. A red-shifted fluorescent substrate for aldehyde dehydrogenase, AldeRed 588-A, for labeling viable ALDH-positive cells[J]. Cancer Research, 2016, 76(14_Supplement): 2508-2508.
Keywords
