2257428-48-9
Chemical Structure
MRS7469
- CAS No.: 2257428-48-9
- Formula:C21H28ClN5O3
- Molecular Weight:433.93
InChIKey: KATPAPFGRPJUHJ-MXKWNSRKSA-N
SMILES: OC[C@]12[C@]([C@@H](N3C4=NC(Cl)=NC(NC(C5CCC5)C6CCC6)=C4N=C3)[C@@H]([C@@H]2O)O)([H])C1
Biological Activity: MRS7469 is a highly selective A1 adenosine receptor (A1AR) agonist with over 2000-fold selectivity over other adenosine receptor subtypes. MRS7469 stably binds to the orthosteric binding site of A1AR, and exhibits extremely high affinity for both humans and mice (e.g., human pKi is 8.67, mouse pKi is 9.43). By activating central A1AR, MRS7469 significantly induces hypothermia, motor inhibition and psychomotor dysfunction, and can be widely used in research related to depression and other relevant fields[1][2][3].
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MRS7469 | MRS7469 is a highly selective A1 adenosine receptor (A1AR) agonist with over 2000-fold selectivity over other adenosine receptor subtypes. MRS7469 stably binds to the orthosteric binding site of A1AR, and exhibits extremely high affinity for both humans and mice (e.g., human pKi is 8.67, mouse pKi is 9.43). By activating central A1AR, MRS7469 significantly induces hypothermia, motor inhibition and psychomotor dysfunction, and can be widely used in research related to depression and other relevant fields. | |||||||||||||||||||||
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- [1]. Solanki N, et al. Adenosine receptor subtype modulators: Insight into molecular mechanisms and their therapeutic application[J]. American Journal of Translational Research, 2025, 17(4): 2376.
- [2]. Jacobson KA, et al. Historical and Current Adenosine Receptor Agonists in Preclinical and Clinical Development. Front Cell Neurosci. 2019;13:124. Published 2019 Mar 28. [Content Brief]
- [3]. Salmaso V, et al. In Silico Drug Design for Purinergic GPCRs: Overview on Molecular Dynamics Applied to Adenosine and P2Y Receptors. Biomolecules. 2020;10(6):812. Published 2020 May 26. [Content Brief]
Keywords
