2286419-03-0
Chemical Structure
BSc5371
- CAS No.: 2286419-03-0
- Formula:C24H31N5O4S
- Molecular Weight:485.60
IUPAC Name: (Z)-N-(2-(diethylamino)ethyl)-2,4-dimethyl-5-((2-oxo-5-(vinylsulfonamido)indolin-3-ylidene)methyl)-1H-pyrrole-3-carboxamide
InChIKey: OXJJSKDUGJXXAV-RGEXLXHISA-N
SMILES: O=C(C1=C(C)NC(/C=C2C(NC3=C\2C=C(NS(=O)(C=C)=O)C=C3)=O)=C1C)NCCN(CC)CC
Biological Activity: BSc5371 is a potent and irreversible FLT3 inhibitor, with Kds of 1.3, 0.83, 1.5, 5.8 and 2.3 nM for mutant FLT3(D835H), FLT3(ITD, D835V), FLT3(ITD, F691L), FLT3-ITD and wild type FLT3wt, respectively. BSc5371 is cytotoxic to FLT3-dependent cell lines[1].
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BSc5371 | BSc5371 is a potent and irreversible FLT3 inhibitor, with Kds of 1.3, 0.83, 1.5, 5.8 and 2.3 nM for mutant FLT3(D835H), FLT3(ITD, D835V), FLT3(ITD, F691L), FLT3-ITD and wild type FLT3wt, respectively. BSc5371 is cytotoxic to FLT3-dependent cell lines. | |||||||||||||||||||||
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Keywords
