BSc5371
BSc5371 is a potent and irreversible FLT3 inhibitor, with Kds of 1.3, 0.83, 1.5, 5.8 and 2.3 nM for mutant FLT3(D835H), FLT3(ITD, D835V), FLT3(ITD, F691L), FLT3-ITD and wild type FLT3wt, respectively. BSc5371 is cytotoxic to FLT3-dependent cell lines.
For research use only. We do not sell to patients.
- CAS No.: 2286419-03-0
- Formula: C24H31N5O4S
- Molecular Weight:485.60
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Kd: 1.3 nM (LT3(D835H)), 0.83 nM (LT3(ITD, D835V)), 1.5 nM (LT3(ITD, F691L)), 5.8 nM (FLT3-ITD), 2.3 nM (FLT3wt)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Jurkat | IC50 |
>1 μM
Compound: 4b; BSc5371
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Cytotoxicity in human Jurkat cells assessed as inhibition of cellular viability after 72 hrs by CellTiter-Glo luminescent assay
Cytotoxicity in human Jurkat cells assessed as inhibition of cellular viability after 72 hrs by CellTiter-Glo luminescent assay
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[PMID: 30742435] |
| MOLM-14 | IC50 |
7.8 nM
Compound: 4b; BSc5371
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Cytotoxicity in human MOLM14 cells assessed as inhibition of cellular viability after 72 hrs by CellTiter-Glo luminescent assay
Cytotoxicity in human MOLM14 cells assessed as inhibition of cellular viability after 72 hrs by CellTiter-Glo luminescent assay
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[PMID: 30742435] |
| MV4-11 | IC50 |
6 nM
Compound: 4b; BSc5371
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Cytotoxicity in human MV4-11 cells assessed as inhibition of cellular viability incubated for 72 hrs by CellTiter-Blue assay
Cytotoxicity in human MV4-11 cells assessed as inhibition of cellular viability incubated for 72 hrs by CellTiter-Blue assay
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[PMID: 30742435] |
| THP-1 | IC50 |
>1 μM
Compound: 4b; BSc5371
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Cytotoxicity in human THP1 cells assessed as inhibition of cellular viability after 72 hrs by CellTiter-Glo luminescent assay
Cytotoxicity in human THP1 cells assessed as inhibition of cellular viability after 72 hrs by CellTiter-Glo luminescent assay
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[PMID: 30742435] |
BSc5371 (5 μM-0.5 nM, 77 hours) exhibits inhibitory activity against FLT3-mutated (MV4-11) cells, with an IC50 of 6 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MV4-11 cells
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Concentration:0.5 nM, 2.5 nM, 5 nM, 25 nM, 50 nM, 250 nM, 500 nM and 5 μM
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Incubation Time:77 hours
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Result:Exhibited inhibitory activity against MV4-11 cells, with an IC50 of 6 nM.
Chemical Information
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CAS No. 2286419-03-0
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Molecular Weight 485.60
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Formula C24H31N5O4S
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SMILES
O=C(C1=C(C)NC(/C=C2C(NC3=C\2C=C(NS(=O)(C=C)=O)C=C3)=O)=C1C)NCCN(CC)CC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BSc5371 Related Classifications
HY-111545 Related Classifications
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