2315268-27-8
2315268-27-8
Chemical Structure
Nemvaleukin alfa
Synonym(s): ALKS 4230; RDB-1450
- CAS No.: 2315268-27-8
- Formula:N/A
- Molecular Weight:(34.41 kDa)
IUPAC Name: ((2R,3R,4S,5R,6R)-3-hydroxy-6-(1H-indol-1-yl)-4-(phosphonooxy)-5-(propionyloxy)tetrahydro-2H-pyran-2-yl)methyl picolinate
SMILES: [Nemvaleukin alfa]
Biological Activity: Nemvaleukin alfa (ALKS 4230) is a IL-2 fusion protein that selectively binds to intermediate-affinity IL-2R. Nemvaleukin alfa is an activator of NK and effector T cells. Nemvaleukin alfa can be used for research of cancer[1][2][3].
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Nemvaleukin alfa | 99.50% | Nemvaleukin alfa (ALKS 4230) is a IL-2 fusion protein that selectively binds to intermediate-affinity IL-2R. Nemvaleukin alfa is an activator of NK and effector T cells. Nemvaleukin alfa can be used for research of cancer. | ||||||||||||||||||||
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References
- [1]. Pan Y, et al, a novel engineered IL-2 fusion protein, drives antitumor immunity and inhibits tumor growth in small cell lung cancer. J Immunother Cancer. 2022 Sep;10(9):e004913. [Content Brief]
- [2]. Lopes JE, et al. Pharmacokinetics and Pharmacodynamic Effects of Nemvaleukin Alfa, a Selective Agonist of the Intermediate-Affinity IL-2 Receptor, in Cynomolgus Monkeys. J Pharmacol Exp Ther. 2021 Nov;379(2):203-210. [Content Brief]
- [3]. Lopes JE, et al. ALKS 4230: a novel engineered IL-2 fusion protein with an improved cellular selectivity profile for cancer immunotherapy. J Immunother Cancer. 2020 Apr;8(1):e000673. [Content Brief]
Keywords
