2. Immunology/Inflammation
  3. Interleukin Related
  4. Nemvaleukin alfa

Nemvaleukin alfa  (Synonyms: ALKS 4230; RDB-1450)

Cat. No.: HY-P99752 Purity: 99.50%
COA

Molarity Calculator

Nemvaleukin alfa (ALKS 4230) is a IL-2 fusion protein that selectively binds to intermediate-affinity IL-2R. Nemvaleukin alfa is an activator of NK and effector T cells. Nemvaleukin alfa can be used for research of cancer.

For research use only. We do not sell to patients.

Nemvaleukin alfa Chemical Structure

Nemvaleukin alfa Chemical Structure

CAS No. : 2315268-27-8

Size Price Stock Quantity
500 μg USD 310 In-stock
1 mg USD 500 In-stock
5 mg USD 1300 In-stock
10 mg USD 2080 In-stock
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Nemvaleukin alfa Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Nemvaleukin alfa (ALKS 4230) is a IL-2 fusion protein that selectively binds to intermediate-affinity IL-2R. Nemvaleukin alfa is an activator of NK and effector T cells. Nemvaleukin alfa can be used for research of cancer[1][2][3].

In Vitro

Nemvaleukin alfa activates lymphocyte subsets from cynomolgus monkey and human samples, with EC50s of 0.45-2.2 nM[2].
Nemvaleukin alfa (0-100 nM, 30 min) induces the activation of intermediate-affinity IL-2R on human cells (HH cells)[3].
Nemvaleukin alfa (0-100 nM, 30 min) induces pSTAT5 in NK cells with an EC50 of 0.45 nM[3].
Nemvaleukin alfa (0.5 nM, 5 days) induces the activation of effector lymphocytes isolated from human peripheral blood[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Nemvaleukin alfa Related Antibodies
In Vivo

Nemvaleukin alfa (6 mg/kg, s.c., every 4 days) inhibits SCLC tumor growth in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SCLC orthotopic model[1]
Dosage: 6 mg/kg
Administration: s.c., every 4 days
Result: Delayed tumor growth and prolonged survival.
Animal Model: Male cynomolgus monkeys (PK Assay)[2]
Dosage: 0.3 or 1 mg/kg
Administration: i.v. or s.c.
Result: Pharmacokinetic profile of Nemvaleukin alfa.
Dose Route dose (mg/kg) Cmax (ng/mL) Tmax (h) T1/2 (h)
i.v. 0.3 6119 0.083 49.5
s.c. 0.3 549 8 61.9
s.c. 1 1035 8 37.3
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Nebacumab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 99.50%

COA (231 KB)

Handling Instructions (2659 KB)
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Nemvaleukin alfa Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nemvaleukin alfa2315268-27-8ALKS 4230 RDB-1450ALKS4230ALKS-4230RDB1450RDB 1450RDB-1450Interleukin RelatedILCancerNKeffector T cellIL-2RIL-2intermediate-affinityInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Nemvaleukin alfa
Cat. No.:
HY-P99752
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.