Nemvaleukin alfa
Based on 1 Customer Validation
Nemvaleukin alfa (ALKS 4230) is a IL-2 fusion protein that selectively binds to intermediate-affinity IL-2R. Nemvaleukin alfa is an activator of NK and effector T cells. Nemvaleukin alfa can be used for research of cancer.
For research use only. We do not sell to patients.
- Purity: 99.50%
- CAS No.: 2315268-27-8
- Molecular Weight:34.41 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Nemvaleukin alfa activates lymphocyte subsets from cynomolgus monkey and human samples, with EC50s of 0.45-2.2 nM[2].
Nemvaleukin alfa (0-100 nM, 30 min) induces the activation of intermediate-affinity IL-2R on human cells (HH cells)[3].
Nemvaleukin alfa (0-100 nM, 30 min) induces pSTAT5 in NK cells with an EC50 of 0.45 nM[3].
Nemvaleukin alfa (0.5 nM, 5 days) induces the activation of effector lymphocytes isolated from human peripheral blood[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:SCLC orthotopic model[1]
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Dosage:6 mg/kg
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Administration:s.c., every 4 days
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Result:Delayed tumor growth and prolonged survival.
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Animal Model:Male cynomolgus monkeys (PK Assay)[2]
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Dosage:0.3 or 1 mg/kg
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Administration:i.v. or s.c.
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Result:Pharmacokinetic profile of Nemvaleukin alfa.
Dose Route dose (mg/kg) Cmax (ng/mL) Tmax (h) T1/2 (h) i.v. 0.3 6119 0.083 49.5 s.c. 0.3 549 8 61.9 s.c. 1 1035 8 37.3
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
ELISA, FACS, Functional assay
Chemical Information
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CAS No. 2315268-27-8
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Appearance Liquid
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Molecular Weight 34.41 kDa
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Color Colorless to light yellow
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SMILES
[Nemvaleukin alfa]
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Synonyms
ALKS 4230; RDB-1450
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (261 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Pan Y, et al, a novel engineered IL-2 fusion protein, drives antitumor immunity and inhibits tumor growth in small cell lung cancer. J Immunother Cancer. 2022 Sep;10(9):e004913. [Content Brief]
[2]. Lopes JE, et al. Pharmacokinetics and Pharmacodynamic Effects of Nemvaleukin Alfa, a Selective Agonist of the Intermediate-Affinity IL-2 Receptor, in Cynomolgus Monkeys. J Pharmacol Exp Ther. 2021 Nov;379(2):203-210. [Content Brief]
[3]. Lopes JE, et al. ALKS 4230: a novel engineered IL-2 fusion protein with an improved cellular selectivity profile for cancer immunotherapy. J Immunother Cancer. 2020 Apr;8(1):e000673. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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