2361566-66-5
2361566-66-5
Chemical Structure
ACI-3024
- CAS. Nr.: 2361566-66-5
- Formula:C22H21FN4O2
- Molecular Weight:392.43
InChIKey: OIXLPYAMXVCZNY-UHFFFAOYSA-N
SMILES: FC=1C=CC2=C(C1)NC3=C2CN(C=4C=CC=5OC(=NC5C4)N6CCOCC6)CC3
Biological Activity: ACI-3024 is an an orally active and highly selective Tau protein aggregation inhibitor. ACI-3024 decrease the β-sheet content and seeding properties of pathological Tau from different Tauopathies, leading to a significant rescue of the Tau-induced neurodegeneration and neuroinflammation in a cellular model. ACI-3024 is promising for research of neurodegenerative diseases[1].
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ACI-3024 | ACI-3024 is an an orally active and highly selective Tau protein aggregation inhibitor. ACI-3024 decrease the β-sheet content and seeding properties of pathological Tau from different Tauopathies, leading to a significant rescue of the Tau-induced neurodegeneration and neuroinflammation in a cellular model. ACI-3024 is promising for research of neurodegenerative diseases. | |||||||||||||||||||||
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References
Keywords
