2368246-78-8
2368246-78-8
Chemical Structure
pan-KRAS-IN-16
- CAS No.: 2368246-78-8
- Formula:C24H26N2O3
- Molecular Weight:390.47
InChIKey: LEFMIEUBWDMNAT-UHFFFAOYSA-N
SMILES: CN(C)CC1=CC(NC2=CC=C(C3=C4OCCOC4=CC=C3)C=C2OC)=CC=C1
Biological Activity: pan-KRAS-IN-16 (Compound 3344) is an anti-RAS small molecule derived from an intracellular antibody fragment with pan-RAS-effector protein-protein interaction inhibitor properties. pan-KRAS-IN-16 binds to a hydrophobic pocket near to the effector-binding switch regions of RAS. pan-KRAS-IN-16 prevents endogenous RAS-dependent signaling in tumor cell lines[1].
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pan-KRAS-IN-16 | pan-KRAS-IN-16 (Compound 3344) is an anti-RAS small molecule derived from an intracellular antibody fragment with pan-RAS-effector protein-protein interaction inhibitor properties. pan-KRAS-IN-16 binds to a hydrophobic pocket near to the effector-binding switch regions of RAS. pan-KRAS-IN-16 prevents endogenous RAS-dependent signaling in tumor cell lines. | |||||||||||||||||||||
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References
Keywords
