2377493-28-0
Chemical Structure
MAT2A-IN-3
- CAS No.: 2377493-28-0
- Formula:C24H16F5N5O3
- Molecular Weight:517.41
IUPAC Name: 8-(4-(difluoromethoxy)phenyl)-6-(2-methyl-2H-indazol-5-yl)-2-(2,2,2-trifluoroethoxy)pyrido[4,3-d]pyrimidin-7(6H)-one
InChIKey: NMLFVOGTUAFIMD-UHFFFAOYSA-N
SMILES: O=C1C(C2=CC=C(OC(F)F)C=C2)=C3N=C(OCC(F)(F)F)N=CC3=CN1C4=CC5=CN(C)N=C5C=C4
Biological Activity: MAT2A-IN-3 is a potent inhibitor of MAT2A. The expression level of MAT2A is abnormally high in several types of tumors, including gastric, colon, liver and pancreatic cancers. MAT2A-IN-3 reduces the proliferative activity of MTAP-deficient cancer cells. MAT2A-IN-3 has the potential for the research of cancer diseases (extracted from patent WO2019191470A1, compound 265)[1].
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MAT2A-IN-3 | MAT2A-IN-3 is a potent inhibitor of MAT2A. The expression level of MAT2A is abnormally high in several types of tumors, including gastric, colon, liver and pancreatic cancers. MAT2A-IN-3 reduces the proliferative activity of MTAP-deficient cancer cells. MAT2A-IN-3 has the potential for the research of cancer diseases (extracted from patent WO2019191470A1, compound 265). | |||||||||||||||||||||
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Keywords
