2378515-04-7
2378515-04-7
Chemical Structure
E197
- CAS No.: 2378515-04-7
- Formula:C19H21ClN2O3S
- Molecular Weight:392.90
InChIKey: KNPZNXSUFBUIGL-RBUKOAKNSA-N
SMILES: O=S1([C@]2(CN(CC2)CC3=CC=C(C=C3)Cl)[C@H](CN1C4=CC=CC=C4)O)=O
Biological Activity: E197 is the inhibitor for DOCK5 that destroys the podosome belt structure of osteoclasts, thereby inhibiting the bone resorption (IC50=3.44 μM in human osteoclast). E197 inhibits the Rac in DOCK5 expressing HEK293 cell with an IC50 of 36 μM. E197 prevents the bone loss in mouse ovariectomized models[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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E197 | 99.91% | E197 is the inhibitor for DOCK5 that destroys the podosome belt structure of osteoclasts, thereby inhibiting the bone resorption (IC50=3.44 μM in human osteoclast). E197 inhibits the Rac in DOCK5 expressing HEK293 cell with an IC50 of 36 μM. E197 prevents the bone loss in mouse ovariectomized models. | ||||||||||||||||||||
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References
Keywords
