E197
Based on 1 Customer Validation
E197 is the inhibitor for DOCK5 that destroys the podosome belt structure of osteoclasts, thereby inhibiting the bone resorption (IC50=3.44 μM in human osteoclast). E197 inhibits the Rac in DOCK5 expressing HEK293 cell with an IC50 of 36 μM. E197 prevents the bone loss in mouse ovariectomized models.
For research use only. We do not sell to patients.
- Purity: 99.91%
- CAS No.: 2378515-04-7
- Formula: C19H21ClN2O3S
- Molecular Weight:392.90
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Osteoclast | IC50 |
3.44 μM
Compound: E197
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Inhibition of resorption activity of mouse peripheral blood cell-derived osteoclasts incubated for 48 hrs by Kossa-staining based assay
Inhibition of resorption activity of mouse peripheral blood cell-derived osteoclasts incubated for 48 hrs by Kossa-staining based assay
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[PMID: 33175535] |
Chemical Information
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CAS No. 2378515-04-7
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Appearance Solid
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Molecular Weight 392.90
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Formula C19H21ClN2O3S
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Color White to off-white
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SMILES
O=S1([C@]2(CN(CC2)CC3=CC=C(C=C3)Cl)[C@H](CN1C4=CC=CC=C4)O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (268 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)