2382378-57-4
Chemical Structure
Monomethyl auristatin E intermediate-17
- CAS No.: 2382378-57-4
- Formula:C27H35NO7S
- Molecular Weight:517.63
IUPAC Name: tert-butyl (S)-2-((1R,2R)-3-(benzyloxy)-2-methyl-3-oxo-1-(tosyloxy)propyl)pyrrolidine-1-carboxylate
InChIKey: HZLKMLDSYIJZET-FGCOXFRFSA-N
SMILES: O=S(O[C@@H]([C@@]1([H])N(CCC1)C(OC(C)(C)C)=O)[C@@H](C)C(OCC2=CC=CC=C2)=O)(C3=CC=C(C=C3)C)=O
Biological Activity: Monomethyl auristatin E intermediate-17 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs)[1].
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Monomethyl auristatin E intermediate-17 | Monomethyl auristatin E intermediate-17 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs). | |||||||||||||||||||||
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