2389988-55-8
Chemical Structure
7,8-Dihydro-8-oxo-7-propargyl-3’-deoxy-3’-fluoro guanosine
- CAS No.: 2389988-55-8
- Formula:C13H14FN5O5
- Molecular Weight:339.28
IUPAC Name: 2-amino-9-((2R,3S,4S,5R)-4-fluoro-3-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-7-(prop-2-yn-1-yl)-7,9-dihydro-3H-purine-6,8-dione
InChIKey: TVTJUIAKQFIXCE-HUKYDQBMSA-N
SMILES: OC[C@@H]1[C@@H](F)[C@@H](O)[C@H](N2C(N(CC#C)C3=C2NC(N)=NC3=O)=O)O1
Biological Activity: 7,8-Dihydro-8-oxo-7-propargyl-3’-deoxy-3’-fluoro guanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. 7,8-Dihydro-8-oxo-7-propargyl-3’-deoxy-3’-fluoro guanosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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7,8-Dihydro-8-oxo-7-propargyl-3’-deoxy-3’-fluoro guanosine | 7,8-Dihydro-8-oxo-7-propargyl-3’-deoxy-3’-fluoro guanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. 7,8-Dihydro-8-oxo-7-propargyl-3’-deoxy-3’-fluoro guanosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | |||||||||||||||||||||
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