2407521-90-6
2407521-90-6
Chemical Structure
Topoisomerase IIα-IN-2
- CAS No.: 2407521-90-6
- Formula:C22H20N4O5
- Molecular Weight:420.42
IUPAC Name: N6-(5-oxo-5H-pyrido[3,2-a]phenoxazine-9-carbonyl)-L-lysine
InChIKey: PWXZZXFILXVNSF-AWEZNQCLSA-N
SMILES: O=C1C2=NC=CC=C2C(C(OC3=C4)=C1)=NC3=CC=C4C(NCCCC[C@H](N)C(O)=O)=O
Biological Activity: Topoisomerase IIα-IN-2 (compound 5) is a potent DNA-binding ligands and topoisomerase IIα inhibitor. Topoisomerase IIα-IN-2 exhibits high antiproliferative activity against human cancer cell lines. Topoisomerase IIα-IN-2 significantly induces DNA damage and arrests cancer cells at G2/M phase[1].
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Topoisomerase IIα-IN-2 | Topoisomerase IIα-IN-2 (compound 5) is a potent DNA-binding ligands and topoisomerase IIα inhibitor. Topoisomerase IIα-IN-2 exhibits high antiproliferative activity against human cancer cell lines. Topoisomerase IIα-IN-2 significantly induces DNA damage and arrests cancer cells at G2/M phase. | |||||||||||||||||||||
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References
Keywords
