2409960-03-6
Chemical Structure
YOK-1304
- CAS No.: 2409960-03-6
- Formula:C28H35NO4
- Molecular Weight:449.58
InChIKey: ZBGAZLLMAKTJEH-RUZDIDTESA-N
SMILES: CC(C)NC[C@@H](O)COC1=CC(OCCCC2=CC=CC=C2)=C(OCC3=CC=CC=C3)C=C1
Biological Activity: YOK-1304 is a p62/Sequestosome-1/SQSTM1 ligand that binds to the p62-ZZ domain. YOK-1304 promotes p62 self-oligomerization and LC3 interaction to facilitate autophagic targeting and p62-dependent selective autophagy. YOK-1304 enhances autophagic flux, induces LC3 puncta formation and p62-LC3 colocalization, and serves as an autophagy-targeting ligand (ATL) that can be linked to target-binding ligands to generate AUTOTAC degraders. YOK-1304 is used in research on cervical cancer and pancreatic cancer[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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YOK-1304 | 98.60% | YOK-1304 is a p62/Sequestosome-1/SQSTM1 ligand that binds to the p62-ZZ domain. YOK-1304 promotes p62 self-oligomerization and LC3 interaction to facilitate autophagic targeting and p62-dependent selective autophagy. YOK-1304 enhances autophagic flux, induces LC3 puncta formation and p62-LC3 colocalization, and serves as an autophagy-targeting ligand (ATL) that can be linked to target-binding ligands to generate AUTOTAC degraders. YOK-1304 is used in research on cervical cancer and pancreatic cancer. | ||||||||||||||||||||
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References
- [1]. Ji CH, et al. The AUTOTAC chemical biology platform for targeted protein degradation via the autophagy-lysosome system. Nature communications. 2022 Feb 16;13(1):904. [Content Brief]
- [2]. Li L, et al. The AUTACE That Degrades KRAS and Engages CD8 T Cells for the Treatment of KRAS/TP53 Co-Mutant Tumors. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2026 Jul;13(37):e18455.
- [3]. Haridas V. Inhibitors to degraders: Changing paradigm in drug discovery. Iscience. 2024 May 17;27(5).
