2412734-00-8
Chemical Structure
JAK3-IN-11
- CAS No.: 2412734-00-8
- Formula:C23H23N5O2
- Molecular Weight:401.46
IUPAC Name: N-(4-(2-((4-morpholinophenyl)amino)pyrimidin-4-yl)phenyl)acrylamide
InChIKey: UXJWKEBWYYWGQW-UHFFFAOYSA-N
SMILES: C=CC(NC1=CC=C(C=C1)C2=NC(NC3=CC=C(C=C3)N4CCOCC4)=NC=C2)=O
Biological Activity: JAK3-IN-11 (Compound 12), a potent, noncytotoxic, irreversible, orally active JAK3 inhibitor with IC50 value of 1.7 nM, has excellent selectivity (>588-fold compared to other JAK isoforms), covalently bind to the ATP-binding pocket in JAK3. JAK3-IN-11 strongly inhibits JAK3-dependent signaling and T cell proliferation, is a promising tool for study autoimmune diseases[1].
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JAK3-IN-11 | JAK3-IN-11 (Compound 12), a potent, noncytotoxic, irreversible, orally active JAK3 inhibitor with IC50 value of 1.7 nM, has excellent selectivity (>588-fold compared to other JAK isoforms), covalently bind to the ATP-binding pocket in JAK3. JAK3-IN-11 strongly inhibits JAK3-dependent signaling and T cell proliferation, is a promising tool for study autoimmune diseases. | |||||||||||||||||||||
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Keywords
