2412761-57-8
2412761-57-8
Chemical Structure
TEAD-IN-1
- CAS No.: 2412761-57-8
- Formula:C15H20F2N2O3S
- Molecular Weight:346.39
IUPAC Name: (E)-N-(5-(2-(4,4-difluorocyclohexyl)vinyl)-6-methoxypyridin-3-yl)methanesulfonamide
InChIKey: KJXYCXXAVTYSCU-ONEGZZNKSA-N
SMILES: CS(=O)(NC1=CC(/C=C/C2CCC(F)(F)CC2)=C(OC)N=C1)=O
Biological Activity: TEAD-IN-1 (Compound 2) is potent TEAD autopalmitoylation inhibitor, with an IC50 of 603 nM. TEAD-IN-1 increases the interaction of TEAD and VGLL4. TEAD-IN-1 decreases the interaction of YAP and TEAD. TEAD-IN-1 can be used for the research of cancer[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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TEAD-IN-1 | 99.43% | TEAD-IN-1 (Compound 2) is potent TEAD autopalmitoylation inhibitor, with an IC50 of 603 nM. TEAD-IN-1 increases the interaction of TEAD and VGLL4. TEAD-IN-1 decreases the interaction of YAP and TEAD. TEAD-IN-1 can be used for the research of cancer. | ||||||||||||||||||||
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References
- [1]. Holden JK, et al. Small Molecule Dysregulation of TEAD Lipidation Induces a Dominant-Negative Inhibition of Hippo Pathway Signaling. Cell Rep. 2020 Jun 23;31(12):107809. [Content Brief]
- [2]. Guarnaccia A D, et al. TEAD-targeting small molecules induce a cofactor switch to regulate the Hippo pathway. bioRxiv, 2024: 2024.11. 15.623512.
Keywords
