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Cat. No.: HY-137479

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TEAD-IN-1

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Based on 1 Customer Validation

TEAD-IN-1 (Compound 2) is potent TEAD autopalmitoylation inhibitor, with an IC₅₀ of 603 nM. TEAD-IN-1 increases the interaction of TEAD and VGLL4. TEAD-IN-1 decreases the interaction of YAP and TEAD. TEAD-IN-1 can be used for the research of cancer.

For research use only. We do not sell to patients.

Purity: 99.43%
CAS No.: 2412761-57-8
Formula: C₁₅H₂₀F₂N₂O₃S
Molecular Weight:346.39

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

TEAD-IN-1 Chemical Structure

CAS No.: 2412761-57-8

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
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Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

TEAD

All YAP Isoforms :

Chemical Information

CAS No. 2412761-57-8
Appearance Solid
Molecular Weight 346.39
Formula C₁₅H₂₀F₂N₂O₃S
Color Off-white to pink
SMILES

CS(=O)(NC1=CC(/C=C/C2CCC(F)(F)CC2)=C(OC)N=C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Holden JK, et al. Small Molecule Dysregulation of TEAD Lipidation Induces a Dominant-Negative Inhibition of Hippo Pathway Signaling. Cell Rep. 2020 Jun 23;31(12):107809. [Content Brief]

[2]. Guarnaccia A D, et al. TEAD-targeting small molecules induce a cofactor switch to regulate the Hippo pathway. bioRxiv, 2024: 2024.11. 15.623512.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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TEAD-IN-1

MCE Bioactive Compound Library

All YAP Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

TEAD-IN-1 Related Classifications

HY-137479 Related Classifications