2414674-71-6
2414674-71-6
Chemical Structure
SUVN-911
- CAS No.: 2414674-71-6
- Formula:C11H14Cl2N2O
- Molecular Weight:261.15
IUPAC Name: (1R,3S,5R)-3-(((6-chloropyridin-3-yl)oxy)methyl)-2-azabicyclo[3.1.0]hexane hydrochloride
InChIKey: VZIQKVIAFWXNFL-ANYFZDTESA-N
SMILES: ClC1=NC=C(OC[C@H]2N[C@@H]3C[C@@H]3C2)C=C1.[H]Cl
Biological Activity: SUVN-911 is a potent, selective, brain penetrated and orally bioavailable neuronal nicotinic acetylcholine α4β2 receptor antagonist, with a Ki of 1.5 nM. SUVN-911 has antidepressant activity[1].
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SUVN-911 | 99.13% | SUVN-911 is a potent, selective, brain penetrated and orally bioavailable neuronal nicotinic acetylcholine α4β2 receptor antagonist, with a Ki of 1.5 nM. SUVN-911 has antidepressant activity. | ||||||||||||||||||||
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References
- [1]. Ramakrishna Nirogi, et al. Discovery and Development of 3-(6-Chloropyridine-3-yloxymethyl)-2-azabicyclo[3.1.0]hexane Hydrochloride (SUVN-911): A Novel, Potent, Selective, and Orally Active Neuronal Nicotinic Acetylcholine α4β2 Receptor Antagonist for the Treatment of Depression. J Med Chem. 2020 Mar 26;63(6):2833-2853. [Content Brief]
Keywords
