2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. nAChR
  4. SUVN-911

SUVN-911 is a potent, selective, brain penetrated and orally bioavailable neuronal nicotinic acetylcholine α4β2 receptor antagonist, with a Ki of 1.5 nM. SUVN-911 has antidepressant activity.

For research use only. We do not sell to patients.

SUVN-911 Chemical Structure

SUVN-911 Chemical Structure

CAS No. : 2414674-71-6

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 477 In-stock
Solution
10 mM * 1 mL in DMSO USD 477 In-stock
Solid
1 mg USD 166 In-stock
5 mg USD 350 In-stock
10 mg USD 580 In-stock
50 mg USD 1650 In-stock
100 mg USD 2550 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of SUVN-911:

SUVN-911 Related Antibodies

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Description

SUVN-911 is a potent, selective, brain penetrated and orally bioavailable neuronal nicotinic acetylcholine α4β2 receptor antagonist, with a Ki of 1.5 nM. SUVN-911 has antidepressant activity[1].

IC50 & Target

Ki: 1.5 nM (α4β2 receptor)[1]
In Vitro

SUVN-911 displays high selectivity for α4β2 over α3β4 nAChR[1].
SUVN-911 shows good selectivity against over 70 receptors which includes GPCRs, ion channels, enzymes, peptides, steroids, second messengers, growth factors and prostaglandins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SUVN-911 Related Antibodies
In Vivo

SUVN-911 is devoid of cardiovascular and gastrointestinal side effects[1].
SUVN-911 (1.0-10.0 mg/kg; p.o.; daily; for 3 days) shows significant antidepressant effects[1].
SUVN-911 shows metabolic stability in rats[1].
SUVN-911 (3 mg/kg; p.o.) has shown high oral exposures, longer half-lives and adequate brain penetration in Wistar rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (180-230 g)[1]
Dosage: 1 mg/kg, 3 mg/kg, 10.0 mg/kg
Administration: Oral administration, daily, for 3 days
Result: Showed antidepressant like activity with no signs of tachyphylaxis.
Animal Model: Male Wistar rats (225 ± 25 g)[1]
Dosage: 3 mg/kg (Pharmacokinetic Analysis)
Administration: Oral administration
Result: AUC=3507 ng*h/mL, T1/2=3.34 hours.
Clinical Trial
Molecular Weight

261.15

Formula

C11H14Cl2N2O
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

ClC1=NC=C(OC[C@H]2N[C@@H]3C[C@@H]3C2)C=C1.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (478.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8292 mL 19.1461 mL 38.2922 mL
5 mM 0.7658 mL 3.8292 mL 7.6584 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.8292 mL 19.1461 mL 38.2922 mL 95.7304 mL
5 mM 0.7658 mL 3.8292 mL 7.6584 mL 19.1461 mL
10 mM 0.3829 mL 1.9146 mL 3.8292 mL 9.5730 mL
15 mM 0.2553 mL 1.2764 mL 2.5528 mL 6.3820 mL
20 mM 0.1915 mL 0.9573 mL 1.9146 mL 4.7865 mL
25 mM 0.1532 mL 0.7658 mL 1.5317 mL 3.8292 mL
30 mM 0.1276 mL 0.6382 mL 1.2764 mL 3.1910 mL
40 mM 0.0957 mL 0.4787 mL 0.9573 mL 2.3933 mL
50 mM 0.0766 mL 0.3829 mL 0.7658 mL 1.9146 mL
60 mM 0.0638 mL 0.3191 mL 0.6382 mL 1.5955 mL
80 mM 0.0479 mL 0.2393 mL 0.4787 mL 1.1966 mL
100 mM 0.0383 mL 0.1915 mL 0.3829 mL 0.9573 mL
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SUVN-911 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SUVN-9112414674-71-6SUVN911SUVN 911nAChRNicotinic acetylcholine receptorsantidepressantdepressionneuronalnicotinicacetylcholineInhibitorinhibitorinhibit

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