1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. nAChR
  3. SUVN-911

SUVN-911 

Cat. No.: HY-136146 Purity: 99.67%
Handling Instructions

SUVN-911 is a potent, selective, brain penetrated and orally bioavailable neuronal nicotinic acetylcholine α4β2 receptor antagonist, with a Ki of 1.5 nM. SUVN-911 has antidepressant activity.

For research use only. We do not sell to patients.

SUVN-911 Chemical Structure

SUVN-911 Chemical Structure

CAS No. : 2414674-71-6

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 495 In-stock
Estimated Time of Arrival: December 31
5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
10 mg USD 750 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2100 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2950 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

SUVN-911 is a potent, selective, brain penetrated and orally bioavailable neuronal nicotinic acetylcholine α4β2 receptor antagonist, with a Ki of 1.5 nM. SUVN-911 has antidepressant activity[1].

IC50 & Target

Ki: 1.5 nM (α4β2 receptor)[1]

In Vitro

SUVN-911 displays high selectivity for α4β2 over α3β4 nAChR[1].
SUVN-911 shows good selectivity against over 70 receptors which includes GPCRs, ion channels, enzymes, peptides, steroids, second messengers, growth factors and prostaglandins[1].

In Vivo

SUVN-911 is devoid of cardiovascular and gastrointestinal side effects[1].
SUVN-911 (1.0-10.0 mg/kg; p.o.; daily; for 3 days) shows significant antidepressant effects[1].
SUVN-911 shows metabolic stability in rats[1].
SUVN-911 (3 mg/kg; p.o.) has shown high oral exposures, longer half-lives and adequate brain penetration in Wistar rats[1].

Animal Model: Male Wistar rats (180-230 g)[1]
Dosage: 1 mg/kg, 3 mg/kg, 10.0 mg/kg
Administration: Oral administration, daily, for 3 days
Result: Showed antidepressant like activity with no signs of tachyphylaxis.
Animal Model: Male Wistar rats (225 ± 25 g)[1]
Dosage: 3 mg/kg (Pharmacokinetic Analysis)
Administration: Oral administration
Result: AUC=3507 ng*h/mL, T1/2=3.34 hours.
Molecular Weight

261.15

Formula

C₁₁H₁₄Cl₂N₂O

CAS No.

2414674-71-6

SMILES

ClC1=NC=C(OC[[email protected]]2N[[email protected]@H]3C[[email protected]@H]3C2)C=C1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (478.65 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8292 mL 19.1461 mL 38.2922 mL
5 mM 0.7658 mL 3.8292 mL 7.6584 mL
10 mM 0.3829 mL 1.9146 mL 3.8292 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

SUVN-911SUVN911SUVN 911nAChRNicotinic acetylcholine receptorsantidepressantdepressionneuronalnicotinicacetylcholineInhibitorinhibitorinhibit

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SUVN-911
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