2417369-99-2
Chemical Structure
GNE-5472
- CAS No.: 2417369-99-2
- Formula:C59H73N7O9S
- Molecular Weight:1056.32
InChIKey: OFBDGLLDQANMKO-DMBCNJBASA-N
SMILES: CC/C(C1=CC=CC=C1)=C(C2=CC=C(O)C=C2)/C3=CC=C(C=C3)OCCN(C(CCOCCOCCC(NC4=NC(C5=CC=CC=C5)=C(NC([C@@H]6CCCN6C([C@@H](NC([C@H](C)NC)=O)C7CCCCC7)=O)=O)S4)=O)=O)C
Biological Activity: GNE-5472 is a potent bifunctional ERα PRRTAC degrader, with its E3 ligand being a pan-IAP antagonist. GNE-5472 antagonizes cIAP1/2, activating the non-classical NF-κB pathway, resulting in a significant upregulation of TNFα expression. GNE-5472 inhibits the proliferation of breast cancer cells and induces cell apoptosis. GNE-5472 can be used for the study of breast cancer[1].
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GNE-5472 | GNE-5472 is a potent bifunctional ERα PRRTAC degrader, with its E3 ligand being a pan-IAP antagonist. GNE-5472 antagonizes cIAP1/2, activating the non-classical NF-κB pathway, resulting in a significant upregulation of TNFα expression. GNE-5472 inhibits the proliferation of breast cancer cells and induces cell apoptosis. GNE-5472 can be used for the study of breast cancer. | |||||||||||||||||||||
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