2417647-40-4
2417647-40-4
Chemical Structure
TD-522
- CAS No.: 2417647-40-4
- Formula:C25H27ClN6O4
- Molecular Weight:510.97
InChIKey: AZQGGAFHYOGHOF-UHFFFAOYSA-N
SMILES: CC(C1=CC=C2N=NN(C(C2=C1)=O)C3CCC(NC3=O)=O)NC(NC4=CC=C(C(Cl)=C4)C(C)(C)C)=O
Biological Activity: TD-522 is a potent and selective molecular glue GSPT1 degrader, with a DC50 of 0.269 nM. TD-522 exhibits strong anti-proliferative effects and induces apoptosis in acute myeloid leukemia (AML) and diffuse large B-cell lymphoma (DLBCL) cells. TD-522 suppresses tumor growth in a TMD-8 xenograft model. TD-522 can be used for AML and DLBCL research[1].
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TD-522 | TD-522 is a potent and selective molecular glue GSPT1 degrader, with a DC50 of 0.269 nM. TD-522 exhibits strong anti-proliferative effects and induces apoptosis in acute myeloid leukemia (AML) and diffuse large B-cell lymphoma (DLBCL) cells. TD-522 suppresses tumor growth in a TMD-8 xenograft model. TD-522 can be used for AML and DLBCL research. | |||||||||||||||||||||
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References
Keywords
