2455519-86-3
2455519-86-3
Chemical Structure
Usnoflast
- CAS No.: 2455519-86-3
- Formula:C21H29N3O3S
- Molecular Weight:403.54
InChIKey: HAMGPBKPACGWND-ZOXUKVPXSA-N
SMILES: C[C@]1(N(CCC1)C)/C=C/S(NC(NC2=C3C(CCC3)=CC4=C2CCC4)=O)(=O)=O
Biological Activity: Usnoflast is the selective, orally active inhibitor for NLRP3 that blocks the release of IL-1β, and exhibits anti-inflammatory activity[1][2].
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Usnoflast | 98.59% | Usnoflast is the selective, orally active inhibitor for NLRP3 that blocks the release of IL-1β, and exhibits anti-inflammatory activity. | ||||||||||||||||||||
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References
- [1]. Sharma, et al. Novel substituted sulfonylurea derivatives as NLRP3 modulators and their preparation. World Intellectual Property Organization, WO2020148619 A1. 2020-07-23.
- [2]. Chatterjee A, et al., A novel selective NLRP3 inhibitor shows disease-modifying potential in animal models of Parkinson's disease. Brain Res. 2024 Nov 1;1842:149129. [Content Brief]
Keywords
