2484919-71-1
Chemical Structure
RET-IN-19
- CAS No.: 2484919-71-1
- Formula:C28H28N6O4S
- Molecular Weight:544.62
IUPAC Name: N-(5-(tert-butyl)isoxazol-3-yl)-2-(4-((6-(4-(methylsulfonyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)phenyl)acetamide
InChIKey: ZBZATSVLKXDTMV-UHFFFAOYSA-N
SMILES: O=C(NC1=NOC(C(C)(C)C)=C1)CC2=CC=C(NC3=C4C(NC(C5=CC=C(S(=O)(C)=O)C=C5)=C4)=NC=N3)C=C2
Biological Activity: RET-IN-19 (compound 59) is a potent RET inhibitor, with IC50 values of 6.8 and 13.51 nM against RET-wt and RET V804M, respectively. RET-IN-19 shows anticancer activity. RET-IN-19 can be used for non-small cell lung cancer (NSCLC) research[1].
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RET-IN-19 | RET-IN-19 (compound 59) is a potent RET inhibitor, with IC50 values of 6.8 and 13.51 nM against RET-wt and RET V804M, respectively. RET-IN-19 shows anticancer activity. RET-IN-19 can be used for non-small cell lung cancer (NSCLC) research. | |||||||||||||||||||||
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Keywords
