1. Protein Tyrosine Kinase/RTK
    JAK/STAT Signaling
    Cell Cycle/DNA Damage
    Epigenetics
    MAPK/ERK Pathway
  2. RET
    EGFR
    Aurora Kinase
    c-Fms
    MAP4K
  3. RET-IN-19

RET-IN-19 

Cat. No.: HY-151377
Handling Instructions

RET-IN-19 (compound 59) is a potent RET inhibitor, with IC50 values of 6.8 and 13.51 nM against RET-wt and RET V804M, respectively. RET-IN-19 shows anticancer activity. RET-IN-19 can be used for non-small cell lung cancer (NSCLC) research.

For research use only. We do not sell to patients.

RET-IN-19 Chemical Structure

RET-IN-19 Chemical Structure

CAS No. : 2484919-71-1

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

RET-IN-19 (compound 59) is a potent RET inhibitor, with IC50 values of 6.8 and 13.51 nM against RET-wt and RET V804M, respectively. RET-IN-19 shows anticancer activity. RET-IN-19 can be used for non-small cell lung cancer (NSCLC) research[1].

IC50 & Target

EGFR

56.78 ± 4. μM (IC50)

Aurora A

0.242 ± 0. μM (IC50)

Aurora B

0.536 ± 45 μM (IC50)

MAP4K4

3.428 ± 0. μM (IC50)

In Vitro

RET-IN-19 (compound 59) shows growth inhibition of LC-2/ad cells which RET-CCDC6 driven, with a GI50 of 0.1067 ± 0.004 μM[1].
RET-IN-19 (3 μM) shows inhibition of LC-2/ad cells migration[1].
RET-IN-19 inhibits EGFR, Aurora A, Aurora B, Nek2, CSF-1R, MAP4K4, NIK, and RET, with IC50 values of 56.78 ± 4.94, 0.242 ± 0.036, 0.536 ± 45.12, >200, 1.65 ± 0.235, 3.428 ± 0.150, >10, and 0.0068 ± 0.0003, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

544.62

Formula

C28H28N6O4S

CAS No.
SMILES

O=C(NC1=NOC(C(C)(C)C)=C1)CC2=CC=C(NC3=C4C(NC(C5=CC=C(S(=O)(C)=O)C=C5)=C4)=NC=N3)C=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
RET-IN-19
Cat. No.:
HY-151377
Quantity:
MCE Japan Authorized Agent: