RET-IN-19
RET-IN-19 (compound 59) is a potent RET inhibitor, with IC50 values of 6.8 and 13.51 nM against RET-wt and RET V804M, respectively. RET-IN-19 shows anticancer activity. RET-IN-19 can be used for non-small cell lung cancer (NSCLC) research.
For research use only. We do not sell to patients.
- CAS No.: 2484919-71-1
- Formula: C28H28N6O4S
- Molecular Weight:544.62
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
|
EGFR 56.78 ± 4. μM (IC50) |
Aurora A 0.242 ± 0. μM (IC50) |
Aurora B 0.536 ± 45 μM (IC50) |
MAP4K4 3.428 ± 0. μM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| LC-2-ad | GI50 |
0.1067 μM
Compound: 59
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Growth inhibition of human LC-2-ad cells measured after 3 days by resazurin staining based fluorescence assay
Growth inhibition of human LC-2-ad cells measured after 3 days by resazurin staining based fluorescence assay
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[PMID: 32823007] |
In Vitro
RET-IN-19 (compound 59) shows growth inhibition of LC-2/ad cells which RET-CCDC6 driven, with a GI50 of 0.1067 ± 0.004 μM[1].
RET-IN-19 (3 μM) shows inhibition of LC-2/ad cells migration[1].
RET-IN-19 inhibits EGFR, Aurora A, Aurora B, Nek2, CSF-1R, MAP4K4, NIK, and RET, with IC50 values of 56.78 ± 4.94, 0.242 ± 0.036, 0.536 ± 45.12, >200, 1.65 ± 0.235, 3.428 ± 0.150, >10, and 0.0068 ± 0.0003, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 2484919-71-1
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Molecular Weight 544.62
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Formula C28H28N6O4S
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SMILES
O=C(NC1=NOC(C(C)(C)C)=C1)CC2=CC=C(NC3=C4C(NC(C5=CC=C(S(=O)(C)=O)C=C5)=C4)=NC=N3)C=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
RET-IN-19 Related Classifications
HY-151377 Related Classifications
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