RET-IN-19
RET-IN-19 (compound 59) is a potent RET inhibitor, with IC50 values of 6.8 and 13.51 nM against RET-wt and RET V804M, respectively. RET-IN-19 shows anticancer activity. RET-IN-19 can be used for non-small cell lung cancer (NSCLC) research.
For research use only. We do not sell to patients.
- CAS No.: 2484919-71-1
- Formula: C28H28N6O4S
- Molecular Weight:544.62
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
|
EGFR 56.78 ± 4. μM (IC50) |
Aurora A 0.242 ± 0. μM (IC50) |
Aurora B 0.536 ± 45 μM (IC50) |
MAP4K4 3.428 ± 0. μM (IC50) |
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Cell Line
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Type | Value | Description | References |
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| LC-2-ad | GI50 |
0.1067 μM
Compound: 59
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Growth inhibition of human LC-2-ad cells measured after 3 days by resazurin staining based fluorescence assay
Growth inhibition of human LC-2-ad cells measured after 3 days by resazurin staining based fluorescence assay
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[PMID: 32823007] |
RET-IN-19 (compound 59) shows growth inhibition of LC-2/ad cells which RET-CCDC6 driven, with a GI50 of 0.1067 ± 0.004 μM[1].
RET-IN-19 (3 μM) shows inhibition of LC-2/ad cells migration[1].
RET-IN-19 inhibits EGFR, Aurora A, Aurora B, Nek2, CSF-1R, MAP4K4, NIK, and RET, with IC50 values of 56.78 ± 4.94, 0.242 ± 0.036, 0.536 ± 45.12, >200, 1.65 ± 0.235, 3.428 ± 0.150, >10, and 0.0068 ± 0.0003, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2484919-71-1
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Molecular Weight 544.62
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Formula C28H28N6O4S
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SMILES
O=C(NC1=NOC(C(C)(C)C)=C1)CC2=CC=C(NC3=C4C(NC(C5=CC=C(S(=O)(C)=O)C=C5)=C4)=NC=N3)C=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
RET-IN-19 Related Classifications
HY-151377 Related Classifications
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