2488208-96-2
Chemical Structure
Topoisomerase II inhibitor 10
- CAS No.: 2488208-96-2
- Formula:C27H20N6O7S
- Molecular Weight:572.55
IUPAC Name: 4-(2-((5-(2-((4-carboxyphenyl)amino)-2-oxoethyl)-6-oxo-5,6-dihydro-[1,2,4]triazolo[3,4-a]phthalazin-3-yl)thio)acetamido)benzoic acid
InChIKey: QTSPXXBYQHQWLQ-UHFFFAOYSA-N
SMILES: O=C(O)C1=CC=C(NC(CSC2=NN=C3N2N(CC(NC4=CC=C(C(O)=O)C=C4)=O)C(C5=C3C=CC=C5)=O)=O)C=C1
Biological Activity: Topoisomerase II inhibitor 10 (compound 32a) is a potent topoisomerase II inhibitor with an IC50 value of 7.45 μM. Topoisomerase II inhibitor 10 causes cell cycle arrest at G2-M phase and induces apoptosis of HepG-2 cells. Topoisomerase II inhibitor 10 has excellent anti-proliferative activities against HepG-2, MCF-7, and HCT-116 cells[1].
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Topoisomerase II inhibitor 10 | Topoisomerase II inhibitor 10 (compound 32a) is a potent topoisomerase II inhibitor with an IC50 value of 7.45 μM. Topoisomerase II inhibitor 10 causes cell cycle arrest at G2-M phase and induces apoptosis of HepG-2 cells. Topoisomerase II inhibitor 10 has excellent anti-proliferative activities against HepG-2, MCF-7, and HCT-116 cells. | |||||||||||||||||||||
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