2490291-68-2
Chemical Structure
Tubulin polymerization-IN-26
- CAS No.: 2490291-68-2
- Formula:C25H23N3O2
- Molecular Weight:397.47
IUPAC Name: (E)-3-(2-ethoxyphenyl)-N-(2-(5-methyl-1H-benzo[d]imidazol-2-yl)phenyl)acrylamide
InChIKey: HOOYTCBSCZSMJT-FYWRMAATSA-N
SMILES: O=C(NC1=CC=CC=C1C2=NC3=CC(C)=CC=C3N2)/C=C/C4=CC=CC=C4OCC
Biological Activity: Tubulin polymerization-IN-26 (compound 12h) can inhibit the polymerization of microtubulin by binding to the colchicine binding site of microtubulin with an IC50 value of 4.64 μM. Tubulin polymerization-IN-26 can induce apoptosis and inhibit cell metastasis or migration, and can be used as a potential compound for lung cancer research[1].
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Tubulin polymerization-IN-26 | Tubulin polymerization-IN-26 (compound 12h) can inhibit the polymerization of microtubulin by binding to the colchicine binding site of microtubulin with an IC50 value of 4.64 μM. Tubulin polymerization-IN-26 can induce apoptosis and inhibit cell metastasis or migration, and can be used as a potential compound for lung cancer research. | |||||||||||||||||||||
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