Tubulin polymerization-IN-26
Tubulin polymerization-IN-26 (compound 12h) can inhibit the polymerization of microtubulin by binding to the colchicine binding site of microtubulin with an IC50 value of 4.64 μM. Tubulin polymerization-IN-26 can induce apoptosis and inhibit cell metastasis or migration, and can be used as a potential compound for lung cancer research.
For research use only. We do not sell to patients.
- CAS No.: 2490291-68-2
- Formula: C25H23N3O2
- Molecular Weight:397.47
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Tubulin polymerization-IN-26 (compound 12h) (0.27-30 μM, 48 hours) shows potent cytotoxic activity against lung cancer cells[1]. Tubulin polymerization-IN-26 (compound 12h) (0.1 μM,0.25 μM,0.5 μM, 24 hours) induces cell apoptosis in a dose-dependent manner by promoting ROS production in cells [1]. Tubulin polymerization-IN-26 (compound 12h) (0.1 μM,0.25 μM,0.5 μM, 24 hours) arrests the cell cycle in G2/M phase[1]. Tubulin polymerization-IN-26 (compound 12h) (0.1 μM,0.25 μM,0.5 μM, 24 hours) inhibits microtubule protein polymerization[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human non-small cell lung cancer A549, Human triple negative breast cancer MDA-MB-231, Mouse melanoma B16-F10, Human breast cancer BT-474, Mouse triple negative breast cancer 4 T1, Rat kidney epithelial cell line NRK-52E
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Concentration:0.27-30 μM
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Incubation Time:48 hours
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Result:Showed cytotoxic activity against A549, MDA-MB-231, B16-F10, BT-474, 4 T1, NRK-52E with IC50 value of 0.29 μM,1.48 μM,1.25 μM,0.42 μM,0.49 μM,1.58 μM respectively.
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Cell Line:Human non-small cell lung cancer A549
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Concentration:0.1 μM,0.25 μM,0.5 μM
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Incubation Time:24 hours
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Result:Changed cell nucleus from normal form to micronucleus with the concentration increasing.
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Cell Line:Human non-small cell lung cancer A549
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Concentration:0.1 μM,0.25 μM,0.5 μM
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Incubation Time:24 hours
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Result:Resulted in more G2/M phase cells production which percentage were 17.6%, 29% and 50.3%, corresponding to concentrations of 0.1 μM, 0.25 μM, and 0.5 μM, respectively. Resulted in even fewer G0/G1 phase cells production which percentage were 41. 1%, 21.2%, and 4.9%, corresponding to concentrations of 0.1 μM, 0.25 μM, and 0.5 μM, respectively.
Chemical Information
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CAS No. 2490291-68-2
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Molecular Weight 397.47
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Formula C25H23N3O2
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SMILES
O=C(NC1=CC=CC=C1C2=NC3=CC(C)=CC=C3N2)/C=C/C4=CC=CC=C4OCC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Tubulin polymerization-IN-26 Related Classifications
HY-149020 Related Classifications
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