2. Cytoskeleton Cell Cycle/DNA Damage Apoptosis
  3. Microtubule/Tubulin Apoptosis
  4. Tubulin polymerization-IN-26

Tubulin polymerization-IN-26 (compound 12h) can inhibit the polymerization of microtubulin by binding to the colchicine binding site of microtubulin with an IC50 value of 4.64 μM. Tubulin polymerization-IN-26 can induce apoptosis and inhibit cell metastasis or migration, and can be used as a potential compound for lung cancer research.

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Tubulin polymerization-IN-26 Chemical Structure

Tubulin polymerization-IN-26 Chemical Structure

CAS No. : 2490291-68-2

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Tubulin polymerization-IN-26 Related Antibodies

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Description

Tubulin polymerization-IN-26 (compound 12h) can inhibit the polymerization of microtubulin by binding to the colchicine binding site of microtubulin with an IC50 value of 4.64 μM. Tubulin polymerization-IN-26 can induce apoptosis and inhibit cell metastasis or migration, and can be used as a potential compound for lung cancer research[1].

In Vitro

Tubulin polymerization-IN-26 (compound 12h) (0.27-30 μM, 48 hours) shows potent cytotoxic activity against lung cancer cells[1].
Tubulin polymerization-IN-26 (compound 12h) (0.1 μM,0.25 μM,0.5 μM, 24 hours) induces cell apoptosis in a dose-dependent manner by promoting ROS production in cells [1].
Tubulin polymerization-IN-26 (compound 12h) (0.1 μM,0.25 μM,0.5 μM, 24 hours) arrests the cell cycle in G2/M phase[1].
Tubulin polymerization-IN-26 (compound 12h) (0.1 μM,0.25 μM,0.5 μM, 24 hours) inhibits microtubule protein polymerization[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tubulin polymerization-IN-26 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: Human non-small cell lung cancer A549, Human triple negative breast cancer MDA-MB-231, Mouse melanoma B16-F10, Human breast cancer BT-474, Mouse triple negative breast cancer 4 T1, Rat kidney epithelial cell line NRK-52E
Concentration: 0.27-30 μM
Incubation Time: 48 hours
Result: Showed cytotoxic activity against A549, MDA-MB-231, B16-F10, BT-474, 4 T1, NRK-52E with IC50 value of 0.29 μM,1.48 μM,1.25 μM,0.42 μM,0.49 μM,1.58 μM respectively.

Apoptosis Analysis[1]

Cell Line: Human non-small cell lung cancer A549
Concentration: 0.1 μM,0.25 μM,0.5 μM
Incubation Time: 24 hours
Result: Changed cell nucleus from normal form to micronucleus with the concentration increasing.

Cell Cycle Analysis[1]

Cell Line: Human non-small cell lung cancer A549
Concentration: 0.1 μM,0.25 μM,0.5 μM
Incubation Time: 24 hours
Result: Resulted in more G2/M phase cells production which percentage were 17.6%, 29% and 50.3%, corresponding to concentrations of 0.1 μM, 0.25 μM, and 0.5 μM, respectively. Resulted in even fewer G0/G1 phase cells production which percentage were 41. 1%, 21.2%, and 4.9%, corresponding to concentrations of 0.1 μM, 0.25 μM, and 0.5 μM, respectively.
Molecular Weight

397.47

Formula

C25H23N3O2
CAS No.
SMILES

O=C(NC1=CC=CC=C1C2=NC3=CC(C)=CC=C3N2)/C=C/C4=CC=CC=C4OCC
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Tubulin polymerization-IN-26 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tubulin polymerization-IN-262490291-68-2Microtubule/TubulinApoptosisCytotoxicityColchicine binding siteCancerMicrotubulinInhibitorinhibitorinhibit

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