2503096-50-0
Chemical Structure
STAT3-IN-11
- CAS No.: 2503096-50-0
- Formula:C20H17NO4
- Molecular Weight:335.35
IUPAC Name: N-(2-(8-hydroxy-3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)ethyl)benzamide
InChIKey: XLSYRTJOLUDGSR-UHFFFAOYSA-N
SMILES: O=C(NCCC(C1=O)=C(C)C(C2=C1C(O)=CC=C2)=O)C3=CC=CC=C3
Biological Activity: STAT3-IN-11 (7a) is a selective STAT3 inhibitor that inhibits the phosphorylation of STAT3 at site pTyr705. STAT3-IN-11 inhibits the phosphorylation of downstream genes (Survivin and Mcl-1) without affecting its upstream tyrosine kinases (Src and JAK2) levels and p-STAT1 expression. STAT3-IN-11 can induce cancer cell apoptosis, which is potential for the discovery of effective STAT3 inhibitors and antitumor agents against cancers[1].
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STAT3-IN-11 | 98.29% | STAT3-IN-11 (7a) is a selective STAT3 inhibitor that inhibits the phosphorylation of STAT3 at site pTyr705. STAT3-IN-11 inhibits the phosphorylation of downstream genes (Survivin and Mcl-1) without affecting its upstream tyrosine kinases (Src and JAK2) levels and p-STAT1 expression. STAT3-IN-11 can induce cancer cell apoptosis, which is potential for the discovery of effective STAT3 inhibitors and antitumor agents against cancers. | ||||||||||||||||||||
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Keywords
