25046-79-1
25046-79-1
Chemical Structure
Glisoxepide
- CAS No.: 25046-79-1
- Formula:C20H27N5O5S
- Molecular Weight:449.52
IUPAC Name: N-(4-(N-(azepan-1-ylcarbamoyl)sulfamoyl)phenethyl)-5-methylisoxazole-3-carboxamide
InChIKey: ZKUDBRCEOBOWLF-UHFFFAOYSA-N
SMILES: O=C(C1=NOC(C)=C1)NCCC2=CC=C(S(=O)(NC(NN3CCCCCC3)=O)=O)C=C2
Biological Activity: Glisoxepide, a sulphonamide derivative, is an orally available nonselective K(ATP) channel blocker, with antihyperglycemic activity and cardiovascular regulation effect[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Glisoxepide | 95.58% | Glisoxepide, a sulphonamide derivative, is an orally available nonselective K(ATP) channel blocker, with antihyperglycemic activity and cardiovascular regulation effect. | ||||||||||||||||||||
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References
- [1]. Sato T, et al. Bepridil, an antiarrhythmic drug, opens mitochondrial KATP channels, blocks sarcolemmal KATP channels, and confers cardioprotection. J Pharmacol Exp Ther. 2006 Jan;316(1):182-8. Epub 2005 Sep 20. [Content Brief]
- [2]. Selvaag E. Photohemolytic potency of oral antidiabetic drugs in vitro: effects of antioxidants and a nitrogen atmosphere. Photodermatol Photoimmunol Photomed. 1996 Aug;12(4):166-70. [Content Brief]
- [3]. Fückel D, et al. Interaction of sulfonylureas with the transport of bile acids into hepatocytes. Eur J Pharmacol. 1992 Mar 31;213(3):393-404. [Content Brief]
Keywords
