2517771-89-8
Chemical Structure
GSK2945 hydrochloride
- CAS No.: 2517771-89-8
- Formula:C20H19Cl3N2O2S
- Molecular Weight:457.80
IUPAC Name: N-(4-chloro-2-methylbenzyl)-N-(4-chlorobenzyl)-1-(5-nitrothiophen-2-yl)methanamine hydrochloride
InChIKey: HRNMOPTYOFRUFF-UHFFFAOYSA-N
SMILES: O=[N+](C1=CC=C(CN(CC2=CC=C(Cl)C=C2C)CC3=CC=C(Cl)C=C3)S1)[O-].Cl
Biological Activity: GSK2945 hydrochloride is a class of tertiary amine, and is a highly specific Rev-erbα/REV-ERBα (mouse/human reverse erythroblastosis virus α) antagonist with EC50s of 21.5 μM and 20.8 μM, respectively. GSK2945 hydrochloride enhances cholesterol 7α-hydroxylase (CYP7A1) level and cholesterol metabolism[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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GSK2945 hydrochloride | 98.49% | GSK2945 hydrochloride is a class of tertiary amine, and is a highly specific Rev-erbα/REV-ERBα (mouse/human reverse erythroblastosis virus α) antagonist with EC50s of 21.5 μM and 20.8 μM, respectively. GSK2945 hydrochloride enhances cholesterol 7α-hydroxylase (CYP7A1) level and cholesterol metabolism. | ||||||||||||||||||||
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Keywords
