2568911-72-6
Chemical Structure
Dezecapavir
Synonym(s): VH-499; VH4011499
- CAS No.: 2568911-72-6
- Formula:C37H29ClF9N9O5S
- Molecular Weight:918.19
InChIKey: JBJQTRRKPQLQQB-VWPQPMDRSA-N
SMILES: FC(F)(CCOC1=NC(N=C(N(C2=O)C3=C(N(N=C4NS(C)(=O)=O)C)C4=C(C=C3)Cl)[C@@H](NC(CN5C6=C(C(C(F)F)=N5)[C@]7([H])[C@@](C(F)6F)([H])C7)=O)CC8=CC(F)=CC(F)=C8)=C2C=C1)F
Biological Activity: Dezecapavir (VH-499) is a HIV-1 capsid protein inhibitor. Dezecapavir exhibits picomolar-level antiviral activity against a variety of HIV-1 laboratory strains and clinical isolates in vitro. Dezecapavir inhibits the early and late stages of the HIV-1 life cycle, blocking nuclear import, reverse transcript production, virion assembly, maturation, and post-nuclear import/pre-integration replication processes. Dezecapavir can be used in studies related to HIV-1 infection[1][2].
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Dezecapavir | 99.97% | Dezecapavir (VH-499) is a HIV-1 capsid protein inhibitor. Dezecapavir exhibits picomolar-level antiviral activity against a variety of HIV-1 laboratory strains and clinical isolates in vitro. Dezecapavir inhibits the early and late stages of the HIV-1 life cycle, blocking nuclear import, reverse transcript production, virion assembly, maturation, and post-nuclear import/pre-integration replication processes. Dezecapavir can be used in studies related to HIV-1 infection. | ||||||||||||||||||||
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- [1]. Thakkar N, et al. Clinical Pharmacokinetics and Safety of Orally Administered VH4011499, a New HIV-1 Capsid Inhibitor, in Adults Without HIV. Infect Dis Ther. 2025;14(5):1011-1025. [Content Brief]
- [2]. Wang C, et al. Preclinical virology profiles of the HIV-1 capsid inhibitors VH4004280 and VH4011499. Antimicrob Agents Chemother. 2025;69(10):e0030925. [Content Brief]
Keywords
