2614310-11-9
2614310-11-9
Chemical Structure
TCI 18
- CAS No.: 2614310-11-9
- Formula:C27H24FN7O7S
- Molecular Weight:609.59
InChIKey: BHBBUIVVUZKDTQ-PTGPVQHPSA-N
SMILES: NC1=NC=NC2=C1N=C(NCC3=CC(C=CC=N4)=C4C=C3)N2[C@H]5[C@H](O)[C@H](O)[C@@H](COC(C6=CC=C(S(F)(=O)=O)C=C6)=O)O5
Biological Activity: TCI 18 is a ligand of HSP72 with a Ki value of 4.7 μM. TCI 18 forms a covalent bond with Lys56 residue of HSP72 via a process involving initial reversible binding, conversion to a pre-covalent complex, and subsequent covalent bond formation. TCI 18 addresses the undruggable target HSP72[1].
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TCI 18 | TCI 18 is a ligand of HSP72 with a Ki value of 4.7 μM. TCI 18 forms a covalent bond with Lys56 residue of HSP72 via a process involving initial reversible binding, conversion to a pre-covalent complex, and subsequent covalent bond formation. TCI 18 addresses the undruggable target HSP72. | |||||||||||||||||||||
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References
Keywords
