TCI 18
TCI 18 is a ligand of HSP72 with a Ki value of 4.7 μM. TCI 18 forms a covalent bond with Lys56 residue of HSP72 via a process involving initial reversible binding, conversion to a pre-covalent complex, and subsequent covalent bond formation. TCI 18 addresses the undruggable target HSP72.
For research use only. We do not sell to patients.
- CAS No.: 2614310-11-9
- Formula: C27H24FN7O7S
- Molecular Weight:609.59
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
TCI 18 (≤ 4.7 μM; 0.08-3 h) potently inhibits recombinant HSP72-NBD with a kinact/KI of 93 M-1s-1, a kinact of 4.4 × 10-4 s-1, an initial Ki of 4.7 μM, and a t1/2 inf of 26 min[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2614310-11-9
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Molecular Weight 609.59
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Formula C27H24FN7O7S
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SMILES
NC1=NC=NC2=C1N=C(NCC3=CC(C=CC=N4)=C4C=C3)N2[C@H]5[C@H](O)[C@H](O)[C@@H](COC(C6=CC=C(S(F)(=O)=O)C=C6)=O)O5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TCI 18 Related Classifications
HY-185764 Related Classifications
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