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Art. -Nr.: HY-185764

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TCI 18

TCI 18 is a ligand of HSP72 with a K_i value of 4.7 μM. TCI 18 forms a covalent bond with Lys56 residue of HSP72 via a process involving initial reversible binding, conversion to a pre-covalent complex, and subsequent covalent bond formation. TCI 18 addresses the undruggable target HSP72.

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CAS. Nr.: 2614310-11-9
Formel: C₂₇H₂₄FN₇O₇S
Molecular Weight:609.59

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

TCI 18 Chemical Structure

CAS. Nr.: 2614310-11-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle HSP Isoform-spezifische Produkte anzeigen :

In Vitro

TCI 18 (≤ 4.7 μM; 0.08-3 h) potently inhibits recombinant HSP72-NBD with a kinact/K_I of 93 M^-1s^-1, a kinact of 4.4 × 10^-4 s^-1, an initial K_i of 4.7 μM, and a t₁/₂ inf of 26 min^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 2614310-11-9
Molecular Weight 609.59
Formel C₂₇H₂₄FN₇O₇S
SMILES

NC1=NC=NC2=C1N=C(NCC3=CC(C=CC=N4)=C4C=C3)N2[C@H]5[C@H](O)[C@H](O)[C@@H](COC(C6=CC=C(S(F)(=O)=O)C=C6)=O)O5
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Pettinger J, et al. Kinetic Optimization of Lysine-Targeting Covalent Inhibitors of HSP72. Journal of medicinal chemistry. 2019 Dec 26;62(24):11383-11398. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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