2635953-17-0
Chemical Structure
Sabizabulin hydrochloride
Synonym(s): VERU-111 hydrochloride; ABI-231 hydrochloride
- CAS No.: 2635953-17-0
- Formula:C21H20ClN3O4
- Molecular Weight:413.85
InChIKey: XJDKAFZMXMMMKD-UHFFFAOYSA-N
SMILES: O=C(C1=CN=C(C2=CNC3=C2C=CC=C3)N1)C4=CC(OC)=C(C(OC)=C4)OC.Cl
Biological Activity: Sabizabulin hydrochloride is a potent orally bioavailable microtubule inhibitor with activity that interacts with the colchicine binding site. Sabizabulin hydrochloride demonstrated significant inhibition of melanoma tumor growth with an average IC50 of 5.2 nM in melanoma and prostate cancer cell lines. Pharmacological screening of Sabizabulin hydrochloride shows it has a low risk of potential side effects[1].
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Sabizabulin hydrochloride | Sabizabulin hydrochloride is a potent orally bioavailable microtubule inhibitor with activity that interacts with the colchicine binding site. Sabizabulin hydrochloride demonstrated significant inhibition of melanoma tumor growth with an average IC50 of 5.2 nM in melanoma and prostate cancer cell lines. Pharmacological screening of Sabizabulin hydrochloride shows it has a low risk of potential side effects. | |||||||||||||||||||||
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Keywords
