2640217-64-5
Chemical Structure
FGFR-IN-8
- CAS No.: 2640217-64-5
- Formula:C27H31Cl2N9O2
- Molecular Weight:584.50
IUPAC Name: 4-(2-((2,6-dichloro-3,5-dimethoxyphenyl)amino)pyridin-3-yl)-N-(1-(1-isopropylpiperidin-4-yl)-1H-pyrazol-4-yl)-1,3,5-triazin-2-amine
InChIKey: QPGRMRIBWAFOOC-UHFFFAOYSA-N
SMILES: CC(N1CCC(N2N=CC(NC3=NC(C4=CC=CN=C4NC5=C(Cl)C(OC)=CC(OC)=C5Cl)=NC=N3)=C2)CC1)C
Biological Activity: FGFR-IN-8 (Compound 17a) is a highly potent and orally active panFGFR inhibitor against wild-type and mutant FGFRs. FGFR-IN-8 shows inhibition with IC50 values of <0.5, 189.1, <0.5, 22.6, <0.5 and 7.30 nM against FGFR1, V564F-FGFR2, N549H-FGFR2, V555M-FGFR3, FGFR3 and FGFR4, respectively. GFR-IN-8 induces cancer cell apoptosis and shows anticancer activities[1].
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FGFR-IN-8 | FGFR-IN-8 (Compound 17a) is a highly potent and orally active panFGFR inhibitor against wild-type and mutant FGFRs. FGFR-IN-8 shows inhibition with IC50 values of <0.5, 189.1, <0.5, 22.6, <0.5 and 7.30 nM against FGFR1, V564F-FGFR2, N549H-FGFR2, V555M-FGFR3, FGFR3 and FGFR4, respectively. GFR-IN-8 induces cancer cell apoptosis and shows anticancer activities. | |||||||||||||||||||||
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Keywords
