2704554-86-7
Chemical Structure
MMH409
- CAS No.: 2704554-86-7
- Formula:C19H16F6N2O3
- Molecular Weight:434.33
InChIKey: JVCQXJCACOCTST-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(N(C(C)C)C(C2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)=O)C=C1)NO
Biological Activity: MMH409 is a selective HDAC8 inhibitor, with an IC50 value of 23 nM and a Kd value of 3.5 nM against human HDAC8, and an IC50 value of 11.64 μM against Schistosoma mansoni HDAC8. MMH409 reduces the viability of newly transformed schistosomula and adult worms of Schistosoma mansoni in vitro. MMH409 serves as a biological probe to investigate the pharmacological knockdown effect of HDAC8 in diseased cells. MMH409 can be used in studies related to neuroblastoma and schistosomiasis[1][2][3][4].
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MMH409 | MMH409 is a selective HDAC8 inhibitor, with an IC50 value of 23 nM and a Kd value of 3.5 nM against human HDAC8, and an IC50 value of 11.64 μM against Schistosoma mansoni HDAC8. MMH409 reduces the viability of newly transformed schistosomula and adult worms of Schistosoma mansoni in vitro. MMH409 serves as a biological probe to investigate the pharmacological knockdown effect of HDAC8 in diseased cells. MMH409 can be used in studies related to neuroblastoma and schistosomiasis. | |||||||||||||||||||||
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- [1]. Abdallah DI, et al. Medicinal chemistry advances in targeting class I histone deacetylases. Explor Target Antitumor Ther. 2023;4(4):757-779. [Content Brief]
- [2]. Hassan MM, et al. Characterization of Conformationally Constrained Benzanilide Scaffolds for Potent and Selective HDAC8 Targeting. Journal of medicinal chemistry. 2020 Aug 13;63(15):8634-8648. [Content Brief]
- [3]. Hassan MM, et al. Phenotypic Screening of Histone Deacetylase (HDAC) Inhibitors against Schistosoma mansoni. ChemMedChem. 2022 Sep 16;17(18):e202100622. [Content Brief]
Keywords
