2712363-60-3
2712363-60-3
Chemical Structure
N-Desmethyl Pimavanserin-d9 hydrochloride
Synonym(s): AC-279-d9 hydrochloride
- CAS 番号: 2712363-60-3
- Formula:C24H24D9ClFN3O2
- Molecular Weight:459.04
InChIKey: JOIUMKQAWHAXIF-UCMPXDKZSA-N
SMILES: O=C(NCC1=CC=C(OC([2H])([2H])C(C([2H])([2H])[2H])([2H])C([2H])([2H])[2H])C=C1)N(CC2=CC=C(F)C=C2)C3CCNCC3.Cl
Biological Activity: N-Desmethyl Pimavanserin-d9 hydrochloride (AC-279-d9 hydrochloride) is the deuterium labeled N-Desmethyl Pimavanserin (HY-135392). N-Desmethyl Pimavanserin is the active metabolite of Pimavanserin. Pimavanserin is a selective inverse agonist of the 5-HT2A receptor with pIC50 and pKd of 8.73 and 9.3, respectively[1].
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N-Desmethyl Pimavanserin-d9 hydrochloride | N-Desmethyl Pimavanserin-d9 hydrochloride (AC-279-d9 hydrochloride) is the deuterium labeled N-Desmethyl Pimavanserin (HY-135392). N-Desmethyl Pimavanserin is the active metabolite of Pimavanserin. Pimavanserin is a selective inverse agonist of the 5-HT2A receptor with pIC50 and pKd of 8.73 and 9.3, respectively. | |||||||||||||||||||||
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N-Desmethyl Pimavanserin (Standard) | ≥98% | Methyl 3,4-dihydroxybenzoate (Standard) is the analytical standard of Methyl 3,4-dihydroxybenzoate. This product is intended for research and analytical applications. Methyl 3,4-dihydroxybenzoate (Protocatechuic acid methyl ester; Methyl protocatechuate) is a major metabolite of antioxidant polyphenols found in green tea. Antioxidant and anti-inflammatory effect. | ||||||||||||||||||||
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N-Desmethyl Pimavanserin | 98.88% | N-Desmethyl Pimavanserin is the active metabolite of Pimavanserin. Pimavanserin is a selective inverse agonist of the 5-HT2A receptor with pIC50 and pKd of 8.73 and 9.3, respectively. | ||||||||||||||||||||
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References
- [1]. Vanover KE, et al. Pharmacological and behavioral profile of N-(4-fluorophenylmethyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl) carbamide (2R,3R)-dihydroxybutanedioate (2:1) (ACP-103), a novel 5-hydroxytryptamine(2A) receptor inverse agonist. J Pharmacol Exp Ther. 2006 May;317(2):910-8. [Content Brief]
